Drug-induced coma differentiated from hypoxemic encephalopathy by flumazenil.
نویسندگان
چکیده
منابع مشابه
Drug-Induced Coma and Delirium
Adverse drug events are common in the ICU and frequently have a negative impact on patient outcome and healthcare costs. A number of factors specific to the ICU setting account for this high incidence, including the complexity of the disease states present and the urgency with which they must be treated, the large number of medications administered, the presence of end-organ dysfunction, the fr...
متن کاملFlumazenil, naloxone and the 'coma cocktail'.
Flumazenil and naloxone are considered to be pharmacologically ideal antidotes. By competitive binding at the molecular target receptors, they are highly specific antagonists of two important drug classes, the benzodiazepines and opioids, respectively. Both antidotes enjoy rapid onset and short duration after parenteral administration, are easily titrated and are essentially devoid of agonist e...
متن کاملDrug-Induced Encephalopathy
Drug-induced encephalopathy is a disease entity often caused by impaired cerebral metabolism that is not attributed to structural brain lesions. However, some drug-induced encephalopathies can develop structural lesions and share other underlying pathophysiological mechanisms (table 2). Leading symptoms are acute or chronic disturbances of consciousness, brain function and personality changes w...
متن کاملReversible coma in Wernicke's encephalopathy.
A case of coma due to Wernicke's encephalopathy complicated by respiratory failure is described. Ventilation and thiamine administration lead to recovery, although Korsakoff's psychosis and ataxia persisted. A review of similar cases of coma emphasizes the absence of diagnostic features, but that if structural disease is excluded the presence of pupillary and ocular signs may support a diagnosi...
متن کاملDiagnostic utility of flumazenil in coma with suspected poisoning.
OBJECTIVE To assess the diagnostic value and safety of the benzodiazepine antagonist flumazenil in patients with coma of unclear origin with suspected poisoning. DESIGN Double blind, placebo controlled, randomised study. SETTING Intensive care unit at a major teaching hospital. PATIENTS 105 Unconscious adults admitted consecutively with suspected drug overdosage during 18 months from a to...
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ژورنال
عنوان ژورنال: Nihon Kyukyu Igakukai Zasshi
سال: 1993
ISSN: 1883-3772,0915-924X
DOI: 10.3893/jjaam.4.648